The role of tight junctions in skin barrier function and dermal absorption

K Bäsler, S Bergmann, M Heisig, A Naegel… - Journal of Controlled …, 2016 - Elsevier
The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

pH-responsive drug delivery systems as intelligent carriers for targeted drug therapy: Brief history, properties, synthesis, mechanism and application

MS Bami, MAR Estabragh, P Khazaeli, M Ohadi… - Journal of Drug Delivery …, 2022 - Elsevier
There are different pH-sensitive systems for biomedical applications that have recently been
considered for pH targeting nanomedicine. In this review, we examine some of the most …

Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases

Q Jing, H Ruan, J Li, Z Wang, L Pei, H Hu, Z He, T Wu… - Biomaterials, 2021 - Elsevier
There is a lack of actively targeting drug delivery carriers for the topical treatment of
epidermal diseases, which results in drug waste and an increased incidence of toxic side …

Polymer-based smart drug delivery systems for skin application and demonstration of stimuli-responsiveness

L Van Gheluwe, I Chourpa, C Gaigne, E Munnier - Polymers, 2021 - mdpi.com
Progress in recent years in the field of stimuli-responsive polymers, whose properties
change depending on the intensity of a signal, permitted an increase in smart drug delivery …

Formulation development of linagliptin solid lipid nanoparticles for oral bioavailability enhancement: role of P-gp inhibition

P Shah, K Chavda, B Vyas, S Patel - Drug delivery and translational …, 2021 - Springer
Linagliptin (LGP), a novel anti-diabetic drug, is a DPP-4 inhibitor used in the treatment of
type II diabetes. One of the major disadvantages of LGP is its low oral bioavailability (29.5%) …

Protein corona formation on colloidal polymeric nanoparticles and polymeric nanogels: impact on cellular uptake, toxicity, immunogenicity, and drug release …

K Obst, G Yealland, B Balzus, E Miceli… - …, 2017 - ACS Publications
The adsorption of biomolecules to the surface of nanoparticles (NPs) following
administration into biological environments is widely recognized. In particular, the “protein …

Formulation, characterization and in vitro release study of 5-fluorouracil loaded chitosan nanoparticles

M Samy, SH Abd El-Alim, A Amin, MMH Ayoub - International journal of …, 2020 - Elsevier
The main objective of this study was to evaluate the most suitable conditions to prepare 5-
fluorouracil (5-FU) loaded chitosan nanoparticles (CSNPs). 5-FU loaded CSNPs were …

Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium

B Balzus, FF Sahle, S Hönzke, C Gerecke… - European Journal of …, 2017 - Elsevier
Controlled delivery of corticosteroids using nanoparticles to the skin and corneal epithelium
may reduce their side effects and maximize treatment effectiveness. Dexamethasone-loaded …

Designing and evaluating pH-responsive electrospun Eudragit® L-100/hydroxypropyl methyl cellulose composite mats for release of propolis as a novel wound …

M Abdi, P Zakeri-Milani, M Ghorbani - Journal of Polymers and the …, 2023 - Springer
Alkaline pH levels in chronic wounds increase the risk of bacterial accumulation. Therefore,
the pH value is a key factor in the wound healing process. In this regard, an attempt was …

pH-sensitive Eudragit® L 100 nanoparticles promote cutaneous penetration and drug release on the skin

P Dong, FF Sahle, SB Lohan, S Saeidpour… - Journal of Controlled …, 2019 - Elsevier
Nanoparticles (NPs) are promising carriers for dermal and transdermal drug delivery.
However, the underlying dynamics of drug release from the NPs, especially, how the …