Recent developments on triazole nucleus in anticonvulsant compounds: a review

MX Song, XQ Deng - Journal of enzyme inhibition and medicinal …, 2018 - Taylor & Francis
Epilepsy is one of the common diseases seriously threatening life and health of human.
More than 50 million people are suffering from this condition and anticonvulsant agents are …

Thiosemicarbazides in the synthesis of five-and six-membered heterocyclic compounds

GA Gazieva, AN Kravchenko - Russian Chemical Reviews, 2012 - iopscience.iop.org
Data on key chemical transformations of thiosemicarbazides resulting in heterocyclic
compounds are generalized and described systematically. Methods for the synthesis of five …

Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents

V Klimešová, J Kočı́, M Pour, J Stachel… - European journal of …, 2002 - Elsevier
A series of 2-alkylsulphanylbenzimidazoles was synthesised and the compounds were
evaluated for their in vitro antimicrobial activity. The structures of the compounds were …

Synthesis and anticancer evaluation of some new unsymmetrical 3, 5-diaryl-4H-1, 2, 4-triazole derivatives

O Bekircan, B Kahveci, M Küçük - Turkish Journal of …, 2006 - journals.tubitak.gov.tr
Abstract A series of 4-arylidenamino-4H-1, 2, 4-triazole derivatives (3-11) were synthesized
from the treatment of 4-amino-4H-1, 2, 4-triazoles (2) with certain aldehydes. Compounds 3 …

Synthesis and structure elucidation of some new thioether derivatives of 1, 2, 4-triazoline-3-thiones and their antimicrobial activities

NN Gülerman, HN Doğan, S Rollas, C Johansson… - Il Farmaco, 2001 - Elsevier
5-(4-Pyridinyl)-4-substituted-2, 4-dihydro-3H-1, 2, 4-triazole-3-thiones and 5-(4-pyridinyl)-4-
substituted-3-(benzoylmethyl) thio-4H-1, 2, 4-triazoles were synthesized. The structures of …

Antibacterial activity of fluorobenzoylthiosemicarbazides and their cyclic analogues with 1, 2, 4-triazole scaffold

U Kosikowska, M Wujec, N Trotsko, W Płonka… - Molecules, 2020 - mdpi.com
The development of drug-resistant bacteria is currently one of the major challenges in
medicine. Therefore, the discovery of novel lead structures for the design of antibacterial …

Synthesis of new bis-1, 2, 4-triazole derivatives

O Bekircan, H Bektas - Molecules, 2006 - mdpi.com
A series of new 1, 2/1, 3-bis [o-(N-methylidenamino-3-aryl-5-phenyl-4H-1, 2, 4-triazole-4-yl)
phenoxy] ethane/propane derivatives 4 were prepared in good yields by treatment of 4 …

Synthesis of 1, 2, 4-triazolines: Base-catalyzed hydrazination/cyclization cascade of α-isocyano esters and amides

D Monge, KL Jensen, I Marin, KA Jørgensen - Organic Letters, 2011 - ACS Publications
A convenient, efficient synthesis of 1, 2, 4-triazolines from α-isocyano esters/amides and
azodicarboxylates is presented. The developed reaction cascade is based on a base …

Cinchona alkaloid squaramide catalyzed enantioselective hydrazination/cyclization cascade reaction of α-isocyanoacetates and azodicarboxylates: synthesis of …

MX Zhao, HL Bi, H Zhou, H Yang… - The Journal of Organic …, 2013 - ACS Publications
An efficient enantioselective hydrazination/cyclization cascade reaction of α-substituted
isocyanoacetates to azodicarboxylates catalyzed by Cinchona alkaloid derived squaramide …

Novel thiosemicarbazide derivatives with 4-nitrophenyl group as multi-target drugs: α-glucosidase inhibitors with antibacterial and antiproliferative activity

M Wos, M Miazga-Karska, AA Kaczor, K Klimek… - Biomedicine & …, 2017 - Elsevier
A series of thiosemicarbazides with 4-nitrophenyl group was obtained in the reaction of
carboxylic acid hydrazides with isothiocyanates. All compounds were checked for their …