Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Background Tumor cells display augmented capability to maintain endoplasmic reticulum
(ER) homeostasis and hijack ER stress pathway for malignant phenotypes under …

In eukaryotes, most secretory and membrane proteins are targeted by an N‐terminal signal
sequence to the endoplasmic reticulum, where the trimeric Sec61 complex serves as protein …

In mammalian cells, one‐third of all polypeptides are integrated into the membrane or
translocated into the lumen of the endoplasmic reticulum (ER) via the Sec61 channel. While …

In human cells, approximately 30% of all polypeptides enter the secretory pathway at the
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …

Dual topologies of proteins at the ER membrane are known for a variety of proteins allowing
the same protein to exert different functions according to the topology adopted. A dual …

The endoplasmic reticulum (ER) of mammalian cells is the central organelle for the
maturation and folding of transmembrane proteins and for proteins destined to be secreted …