[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

[HTML][HTML] Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

[HTML][HTML] The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

TP Peacock, DH Goldhill, J Zhou, L Baillon… - Nature …, 2021 - nature.com
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion …

[HTML][HTML] Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

L Braga, H Ali, I Secco, E Chiavacci, G Neves… - Nature, 2021 - nature.com
COVID-19 is a disease with unique characteristics that include lung thrombosis, frequent
diarrhoea, abnormal activation of the inflammatory response and rapid deterioration of lung …

[HTML][HTML] SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

L Zhang, CB Jackson, H Mou, A Ojha, H Peng… - Nature …, 2020 - nature.com
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally.
We therefore compare the properties of the mutated S protein (SG614) with the original …

[HTML][HTML] Mechanisms of SARS-CoV-2 transmission and pathogenesis

AG Harrison, T Lin, P Wang - Trends in immunology, 2020 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …

[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

FP Veras, MC Pontelli, CM Silva… - Journal of Experimental …, 2020 - rupress.org
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to
cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …

Pathophysiological mechanisms of liver injury in COVID‐19

AD Nardo, M Schneeweiss‐Gleixner… - Liver …, 2021 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute
Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide …

[HTML][HTML] The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L Zhang, CB Jackson, H Mou, A Ojha, ES Rangarajan… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Abstract SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral
spike (S) protein predominate over time in locales where it is found, implying that this …