Abstract Coronavirus disease 2019 (Covid-19) is a worldwide infectious disease caused by
severe acute respiratory coronavirus 2 (SARS-CoV-2). In severe SARS-CoV-2 infection …

The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely
distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability …

Ferroptosis, a novel type of programmed cell death, is involved in inflammation and
oxidation of various human diseases, including diabetic kidney disease. The present study …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …

COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory …

Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …

High-mobility group box 1 (HMGB1), a multifunctional nuclear protein, exists mainly within
the nucleus of all mammal eukaryotic cells. It is actively secreted by the necrotic cells as a …

Highlights•Pectic polysaccharides interact with immune cells to regulate inflammation.•
Homogalacturonan is a preferential domain for alleviating acute inflammation.• …