Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

We introduce the TRUST4 open-source algorithm for reconstruction of immune receptor
repertoires in αβ/γδ T cells and B cells from RNA-sequencing (RNA-seq) data. Compared …

Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We
hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes …

RNA sequencing (RNA-seq) has become an exemplary technology in modern biology and
clinical science. Its immense popularity is due in large part to the continuous efforts of the …

Human memory B cells (MBCs) are generated and diversified in secondary lymphoid tissues
throughout the organism. A paired immunoglobulin (Ig)-gene repertoire analysis of …

Background Sepsis is a highly heterogeneous syndrome, which has hindered the
development of effective therapies. This has prompted investigators to develop a precision …

Several human B cell subpopulations are recognised in the peripheral blood, which play
distinct roles in the humoral immune response. These cells undergo developmental and …

A hallmark of T cell dependent (TD) humoral immune responses is the generation of long–
lived memory B cells. The generation of these cells occurs primarily in the germinal center …

We applied our computational algorithm TRUST4 to assemble immune receptor (T-cell
receptor/B-cell receptor) repertoires from approximately 12,000 RNA sequencing samples …

Antigen-specific T cells play a central role in the adaptive immune response and come in a
wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in …