C–H activation: toward sustainability and applications
T Dalton, T Faber, F Glorius - ACS Central Science, 2021 - ACS Publications
Since the definition of the “12 Principles of Green Chemistry” more than 20 years ago,
chemists have become increasingly mindful of the need to conserve natural resources and …
chemists have become increasingly mindful of the need to conserve natural resources and …
Radical C(sp3)–H functionalization and cross-coupling reactions
C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …
Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts
In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …
reactions are widely performed during single and multistep synthesis. However, besides the …
Organic synthesis provides opportunities to transform drug discovery
DC Blakemore, L Castro, I Churcher, DC Rees… - Nature …, 2018 - nature.com
Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …
limiting factor in drug-discovery projects. Here we present some current challenges in …
Electronic control over site-selectivity in hydrogen atom transfer (HAT) based C (sp 3)–H functionalization promoted by electrophilic reagents
M Galeotti, M Salamone, M Bietti - Chemical Society Reviews, 2022 - pubs.rsc.org
The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …
approaches to develop new synthetic methodology. Among the available strategies for …
Aliphatic C–H oxidations for late-stage functionalization
The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …
Residue-specific peptide modification: a chemist's guide
Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …
pace, making it increasingly time consuming for practitioners to identify the best chemical …
The interplay of polar effects in controlling the selectivity of radical reactions
Radical reactivity is a powerful tool for molecular construction that often provides bond-
forming strategies and retrosynthetic disconnections complementary to those available …
forming strategies and retrosynthetic disconnections complementary to those available …
Site-selective C–H functionalization by decatungstate anion photocatalysis: synergistic control by polar and steric effects expands the reaction scope
The synergistic control of the SH2 transition states of hydrogen abstraction by polar and
steric effects provides a promising strategy in achieving site-selective C (sp3)–H …
steric effects provides a promising strategy in achieving site-selective C (sp3)–H …
Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …
functions. Understanding the complexities of protein higher-order structures and dynamics …