Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …

Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

The G protein‐coupled receptor (GPCR) Proteolysis Site (GPS) of cell‐adhesion GPCRs
and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis …

Latrophilins (LPHNs) are a small family of G protein-coupled receptors known to mediate the
massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their …

In nonneuronal cells, the cell surface protein dystroglycan links the intracellular cytoskeleton
(via dystrophin or utrophin) to the extracellular matrix (via laminin, agrin, or perlecan) …

Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8),
suggesting that about 80% of phenotypic variance is due to genetic factors. We used the …

We recently identified genes encoding tumor endothelial markers (TEM s) that displayed
elevated expression during tumor angiogenesis. From both biological and clinical points of …

Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for
establishing and maintaining cell polarity, neurite differentiation and regulated exocytosis …

Latrophilin-1,-2, and-3 are adhesion-type G protein-coupled receptors that are auxiliary α-
latrotoxin receptors, suggesting that they may have a synaptic function. Using pulldowns, we …