The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …

Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of
protease genes in the human genome, are secreted serine proteases with diverse …

Abstract Background: Updated National Academy of Clinical Biochemistry (NACB)
Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been …

Ovarian carcinomas relate to highest death rate in gynecologic malignancies as absence of
symptoms shield the disease in the early stage. Current evidences have been devoted to …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases
and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are …

Kallikreins are a subgroup of the serine protease enzyme family. Until recently, it was
thought that the human kallikrein gene family contained only three members. In the past 3 …

Prostate specific antigen (PSA) or human kallikrein 3 (hK3) has long been an effective
biomarker for prostate cancer. Now, other members of the tissue kallikrein (KLK) gene family …

Purpose: The discovery of new ovarian cancer biomarkers that are suitable for early disease
diagnosis and prognosis may ultimately lead to improved patient management and …

Human tissue kallikreins (KLKs) are attracting increased attention due to their role as
biomarkers for the screening, diagnosis, prognosis, and monitoring of various cancers …