Hypericin: A natural anthraquinone as promising therapeutic agent

JJ Wu, J Zhang, CY Xia, K Ding, XX Li, XG Pan, JK Xu… - Phytomedicine, 2023 - Elsevier
Background: Hypericin is a prominent secondary metabolite mainly existing in genus
Hypericum. It has become a research focus for a quiet long time owing to its extensively …

The CAM model—Q&A with experts

D Fischer, G Fluegen, P Garcia… - Cancers, 2022 - mdpi.com
Simple Summary The chorioallantoic membrane (CAM) model is an alternative in vivo test
system for the study of hallmarks of cancer such as angiogenesis, tumor growth, immune …

Chorioallantoic membrane models of various avian species: Differences and applications

B Kundeková, M Máčajová, M Meta, I Čavarga, B Bilčík - Biology, 2021 - mdpi.com
Simple Summary The chorioallantoic membrane of an avian embryo is a simple, low-cost,
low-maintenance, and well-available in vivo animal model with many advantages in the field …

pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

E Beňová, V Hornebecq, V Zeleňák, V Huntošová… - Applied Surface …, 2021 - Elsevier
A pH-responsive drug delivery system composed of N-(propyl) aniline (N-ANI) modified
mesoporous silica nanoparticles as a carrier, and β-cyclodextrin (β-CD) as a cap was …

Biophysical characterization and anticancer activities of photosensitive phytoanthraquinones represented by hypericin and its model compounds

V Verebová, J Beneš, J Staničová - Molecules, 2020 - mdpi.com
Photosensitive compounds found in herbs have been reported in recent years as having a
variety of interesting medicinal and biological activities. In this review, we focus on …

Alkyl Chain length in poly (2-oxazoline)-based amphiphilic gradient copolymers regulates the delivery of hydrophobic molecules: a case of the biodistribution and the …

V Huntosova, S Datta, L Lenkavska… - …, 2021 - ACS Publications
Self-assembled nanostructures of amphiphilic gradient copoly (2-oxazoline) s have recently
attracted attention as promising delivery systems for the effective delivery of hydrophobic …

Autophagy and apoptosis induced in U87 MG glioblastoma cells by hypericin-mediated photodynamic therapy can be photobiomodulated with 808 nm light

V Pevna, G Wagnières, V Huntosova - Biomedicines, 2021 - mdpi.com
Glioblastoma is one of the most aggressive types of tumors. Although few treatment options
are currently available, new modalities are needed to improve prognosis. In this context …

Hypericin photodynamic activity in DPPC liposomes–part II: stability and application in melanoma B16-F10 cancer cells

FAP de Morais, RS Gonçalves, BH Vilsinski… - Photochemical & …, 2020 - pubs.rsc.org
Hypericin (Hyp) is considered a promising photosensitizer for Photodynamic Therapy (PDT),
due to its high hydrophobicity, affinity for cell membranes, low toxicity and high …

Singlet oxygen lifetime changes in dying glioblastoma cells

A Hovan, V Pevna, V Huntosova… - Photochemistry and …, 2024 - Wiley Online Library
Time‐resolved phosphorescence detection was employed to determine the lifetime of
singlet oxygen in live cells. Using hypericin as a photosensitizer, singlet oxygen was …

Cytotoxicity study and influence of SBA-15 surface polarity and pH on adsorption and release properties of anticancer agent pemetrexed

M Almáši, E Beňová, V Zeleňák, B Madaj… - Materials Science and …, 2020 - Elsevier
Mesoporous material SBA-15 was functionalized with different polar and nonpolar groups: 3-
aminopropyl,(SBA-15-NH 2), 3-isocyanatopropyl (SBA-15-NCO), 3-mercaptopropyl (SBA-15 …