Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …
fourth-leading cause of death. Hyperglycemia induces various complications, including …
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …
factors that are involved in regulating glucose and lipid homeostasis, inflammation …
Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities
CJ Omiecinski, JP Vanden Heuvel… - Toxicological …, 2011 - academic.oup.com
To commemorate the 50th anniversary of the Society of Toxicology, this special edition
article reviews the history and current scope of xenobiotic metabolism and transport, with …
article reviews the history and current scope of xenobiotic metabolism and transport, with …
[图书][B] The toxicology of fishes
RT Di Giulio, DE Hinton - 2008 - taylorfrancis.com
When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …
Bioactivity profiling of per-and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure
Per-and polyfluoroalkyl substances (PFAS) are a broad class of hundreds of fluorinated
chemicals with environmental health concerns due to their widespread presence and …
chemicals with environmental health concerns due to their widespread presence and …
Activation of mouse and human peroxisome proliferator–activated receptors (α, β/δ, γ) by perfluorooctanoic acid and perfluorooctane sulfonate
ML Takacs, BD Abbott - Toxicological Sciences, 2007 - academic.oup.com
This study evaluates the potential for perfluorooctanoic acid (PFOA) and perfluorooctane
sulfonate (PFOS) to activate peroxisome proliferator–activated receptors (PPARs), using a …
sulfonate (PFOS) to activate peroxisome proliferator–activated receptors (PPARs), using a …
Peroxisome proliferator-activated receptor agonists and antagonists: A patent review (2014-present)
I Takada, M Makishima - Expert opinion on therapeutic patents, 2020 - Taylor & Francis
Introduction: Peroxisome proliferator-activated receptors (PPARs), PPARα, PPARδ, and
PPARγ, play an important role in the regulation of various physiological processes …
PPARγ, play an important role in the regulation of various physiological processes …
Perfluorinated compounds: emerging POPs with potential immunotoxicity
Perfluorinated compounds (PFCs) have been recognized as an important class of
environmental contaminants commonly detected in blood samples of both wildlife and …
environmental contaminants commonly detected in blood samples of both wildlife and …
Thiazolidine-2, 4-diones: Progress towards multifarious applications
VS Jain, DK Vora, CS Ramaa - Bioorganic & medicinal chemistry, 2013 - Elsevier
The promising activity shown by compounds containing thiazolidine-2, 4-dione nucleus in
numerous categories such as anti-hyperglycaemics, aldose reductase inhibitors, anti …
numerous categories such as anti-hyperglycaemics, aldose reductase inhibitors, anti …