From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance

C Souque, I González Ojeda… - Annual Review of …, 2024 - annualreviews.org
Tackling the challenge created by antibiotic resistance requires understanding the
mechanisms behind its evolution. Like any evolutionary process, the evolution of …

Forecasting antimicrobial resistance evolution

J Rolff, S Bonhoeffer, C Kloft, R Leistner, R Regoes… - Trends in …, 2024 - cell.com
Antimicrobial resistance (AMR) is a major global health issue. Current measures for tackling
it comprise mainly the prudent use of drugs, the development of new drugs, and rapid …

[HTML][HTML] Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom

A Boaro, L Ageitos, MDT Torres, EB Blasco… - Cell Reports Physical …, 2023 - cell.com
Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising
alternative source of antibiotics. Here, through structure-function-guided design, we convert …

Design principles of collateral sensitivity-based dosing strategies

LBS Aulin, A Liakopoulos, PH van der Graaf… - Nature …, 2021 - nature.com
Collateral sensitivity (CS)-based antibiotic treatments, where increased resistance to one
antibiotic leads to increased sensitivity to a second antibiotic, may have the potential to limit …

A novel quorum quencher, Rhodococcus pyridinivorans XN-36, is a powerful agent for the biocontrol of soft rot disease in various host plants

Z Zhou, X Wu, J Li, Y Zhang, Y Huang, W Zhang, Y Shi… - Biological Control, 2022 - Elsevier
Quorum sensing (QS) is a microbial cell–cell communication mechanism that regulates the
virulence factor production in numerous pathogens, which plays a key role in microbial …

Combinatorial screening SlipChip for rapid phenotypic antimicrobial susceptibility testing

X Li, X Liu, Z Yu, Y Luo, Q Hu, Z Xu, J Dai, N Wu… - Lab on a Chip, 2022 - pubs.rsc.org
Antimicrobial resistance (AMR) by bacteria is a serious global threat, and a rapid, high-
throughput, and easy-to-use phenotypic antimicrobial susceptibility testing (AST) method is …

Antibiotic-loaded lipid-based nanocarrier: A promising strategy to overcome bacterial infection

MAB Henostroza, GD Tavares, MN Yukuyama… - International Journal of …, 2022 - Elsevier
Abstract According to the World Health Organization (WHO) and Centers for Disease Control
and Prevention (CDC), bacterial infections are one of the greatest threats to global health …

Antimicrobial Peptide Screening for Designing Custom Bactericidal Hydrogels

M Recktenwald, M Kaur, MM Benmassaoud, A Copling… - Pharmaceutics, 2024 - mdpi.com
Staphylococcus aureus (S. aureus) is an opportunistic pathogen that lives on surfaces and
skin and can cause serious infections inside the body. Antimicrobial peptides (AMPs) are …

Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

N Morales-Durán, A León-Buitimea… - Heliyon, 2024 - cell.com
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are
the main drivers in developing drug-resistant bacteria. The emergence of the rapid global …

Occurrence and Multidrug Resistance in Strains of Listeria monocytogenes Recovered from the Anaerobic Co-Digestion Sludge Contained in a Single Stage Steel …

CE Manyi-Loh, AI Okoh, R Lues - Microorganisms, 2023 - mdpi.com
L. monocytogenes is a zoonotic foodborne pathogen with inherent adaptability to tolerate
environmental and physiological stresses, thereby causing severe disease outbreaks …