Abstract Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and
their plasticity in relationship to bone growth, articulation, and formation of the trabeculae …

Why only certain species can regenerate their appendages (eg tails and limbs) remains one
of the biggest mysteries of nature. Unlike anuran tadpoles and salamanders, humans and …

The mechanisms that regulate growth and size of the regenerating limb in tetrapods such as
the Mexican axolotl are unknown. Upon the completion of the developmental stages of …

While the axolotl's ability to completely regenerate amputated limbs is well known and
studied, the mechanism of axolotl bone fracture healing remains poorly understood. One …

Early events during axolotl limb regeneration include an immune response and the
formation of a wound epithelium. These events are linked to a clearance of damaged tissue …

Skeletal development is well known in temnospondyls, the most diverse group of Paleozoic
and Mesozoic amphibians. However, the elements of carpus and tarsus (ie., the …

In processes such as development and regeneration, where large cellular and tissue
rearrangements occur, cell fate and behaviour are strongly influenced by tissue mechanics …

Limb regeneration in salamanders is achieved by a complex coordination of various
biological processes and requires the proper integration of new tissue with old. Among the …

Background The regenerative capacity of organisms declines throughout evolution, and
mammals lack the ability to regenerate limbs after injury. Past approaches to achieving …

The size and shape of the tetrapod limb play central roles in their functionality and the
overall physiology of the organism. In this minireview we will discuss observations on mutant …