There is a growing appreciation for the role of vaccines in confronting the problem of
antimicrobial resistance (AMR). Vaccines can reduce the prevalence of resistance by …

Colonization of the human nasopharynx by pneumococcus is extremely common and is both
the primary reservoir for transmission and a prerequisite for disease. Current vaccines …

Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was
developed to identify neoantigens empirically by expressing each unique patient-specific …

Characterizing the immune response to pneumococcal proteins is critical in understanding
this bacterium's epidemiology and vaccinology. Probing a custom-designed proteome …

Non-serotype-specific protein-based pneumococcal vaccines have received extensive
research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal …

ABSTRACT Introduction: Epidemiologic evaluations of Streptococcus pneumoniae
nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer …

Th17 cells are characterized as preferential producer of interleukins including IL-17A, IL-
17F, IL-21 and IL-22. Corresponding receptors of these cytokines are expressed on number …

Streptococcus pneumoniae (the pneumococcus) is a nasopharyngeal commensal and
respiratory pathogen. Most isolates express a capsule, the species-wide diversity of which …

Host immunity is a major driver of pathogen evolution and thus a major determinant of
pathogen diversity. Explanations for pathogen diversity traditionally assume simple …

Streptococcus pneumoniae remains one of the most frequent bacterial causes of morbidity
and mortality worldwide. National immunization programs implementing pneumococcal …