Skeletal muscle fibers are classified into fiber types, in particular, slow twitch versus fast
twitch. Muscle fiber types are generally defined by the particular myosin heavy chain …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …

Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …

Muscle and its connective tissue are intimately linked in the embryo and in the adult,
suggesting that interactions between these tissues are crucial for their development …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …

Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric
myofilament proteins are essential players in the contraction of striated muscles. The …

The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …

A shift from oxidative to glycolytic metabolism has been associated with skeletal muscle
insulin resistance in type 2 diabetes,,,,. However, whether this metabolic switch is …