The nerve growth factor 35 years later

R Levi-Montalcini - Science, 1987 - science.org
Embryogenesis is in some way a model system. It has always been distinguished bythe
aeactitude, evn punctio, of its anatomical descriptions. An experiment by one of the great …

Exploring the pathogenesis of Alzheimer disease in basal forebrain cholinergic neurons: converging insights from alternative hypotheses

XQ Chen, WC Mobley - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …

Cholinergic system during the progression of Alzheimer's disease: therapeutic implications

EJ Mufson, SE Counts, SE Perez… - Expert review of …, 2008 - Taylor & Francis
Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Trophic factors and neuronal survival

YA Barde - Neuron, 1989 - Elsevier
A recurrent observation in the development of the nervous system is the generation of
neurons followed by their large scale elimination. This phenomenon, usually referred to as …

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

DR Kaplan, D Martin-Zanca, LF Parada - Nature, 1991 - nature.com
Nerve growth factor (NGF) is a neurotrophic factor responsible for the differentiation and
survival of sympathetic and sensory neurons as well as selective populations of cholinergic …

Expression and structure of the human NGF receptor

D Johnson, A Lanahan, CR Buck, A Sehgal, C Morgan… - Cell, 1986 - cell.com
The nucleotide sequence for the human nerve growth factor (NGF) receptor has been
determined. The 3.8 kb receptor mRNA encodes a 427 amino acid protein containing a 28 …

[PDF][PDF] The nerve growth factor: thirty‐five years later.

R Levi‐Montalcini - The EMBO journal, 1987 - embopress.org
Introduction: Neurogenesis and its early experimental approach'Embryogenesis is in some
way a model system. It has always been distinguished by the exactitude even puctilio, of its …

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

RF Alderson, AL Alterman, YA Barde, RM Lindsay - Neuron, 1990 - cell.com
Brain-derived neurotrophic factor (BDN F) was found to promote the survival of E17 rat
embryo septal cholinergic neurons in culture, as assessed by a histochemical stain for …

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

W Fischer, K Wictorin, A Björklund, LR Williams… - Nature, 1987 - nature.com
In aged rodents, impairments in learning and memory have been associated with an age-
dependent decline in forebrain of cholinergic function1, and recent evidence indicates that …

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth …

F Zafra, E Castren, H Thoenen… - Proceedings of the …, 1991 - National Acad Sciences
In the central nervous system brain-derived neurotrophic factor (BDNF) and nerve growth
factor (NGF) are predominantly located in neurons. Here we demonstrate that the balance …