Alzheimer disease (AD) represents an oncoming epidemic that without an effective treatment promises to exact extraordinary financial and emotional burdens. Studies of …
EJ Mufson, SE Counts, SE Perez… - Expert review of …, 2008 - Taylor & Francis
Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …
A recurrent observation in the development of the nervous system is the generation of neurons followed by their large scale elimination. This phenomenon, usually referred to as …
Nerve growth factor (NGF) is a neurotrophic factor responsible for the differentiation and survival of sympathetic and sensory neurons as well as selective populations of cholinergic …
D Johnson, A Lanahan, CR Buck, A Sehgal, C Morgan… - Cell, 1986 - cell.com
The nucleotide sequence for the human nerve growth factor (NGF) receptor has been determined. The 3.8 kb receptor mRNA encodes a 427 amino acid protein containing a 28 …
R Levi‐Montalcini - The EMBO journal, 1987 - embopress.org
Introduction: Neurogenesis and its early experimental approach'Embryogenesis is in some way a model system. It has always been distinguished by the exactitude even puctilio, of its …
RF Alderson, AL Alterman, YA Barde, RM Lindsay - Neuron, 1990 - cell.com
Brain-derived neurotrophic factor (BDN F) was found to promote the survival of E17 rat embryo septal cholinergic neurons in culture, as assessed by a histochemical stain for …
W Fischer, K Wictorin, A Björklund, LR Williams… - Nature, 1987 - nature.com
In aged rodents, impairments in learning and memory have been associated with an age- dependent decline in forebrain of cholinergic function1, and recent evidence indicates that …
F Zafra, E Castren, H Thoenen… - Proceedings of the …, 1991 - National Acad Sciences
In the central nervous system brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are predominantly located in neurons. Here we demonstrate that the balance …