Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …

Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still
result in poor outcomes and developing the novel targets and therapeutic strategies are …

Axonal degeneration is a key and early pathological feature in traumatic and
neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal …

Axon guidance molecules (AGM) are critical regulators of neural development and play a
vital role in guiding axons to their target regions during spinal cord development. The correct …

Spinal cord injuries (SCI) cause permanent functional impairments due to interruption of
motor and sensory pathways. Regeneration of axons does not occur due to lack of intrinsic …

This paper explores the potential of rAAV2-retro to deliver gene modifying cargoes to the
cells of origin of multiple pathways that are interrupted by spinal cord injury (SCI) …

Rho-associated protein kinase (ROCK) is a serine-threonine kinase originally identified as a
crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK …

Limited axon regeneration in the injured adult mammalian central nervous system (CNS)
usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory …

Axonal damage is an early step in traumatic and neurodegenerative disorders of the central
nervous system (CNS). Damaged axons are not able to regenerate sufficiently in the adult …