In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Dietary protein is critical for the maintenance of musculoskeletal health, where appropriate
intake (ie, source, dose, timing) can mitigate declines in muscle and bone mass and/or …

Focal adhesion kinase (FAK) is an attachment complex protein associated with the
regulation of muscle mass through as-of-yet unclear mechanisms. We tested whether FAK is …

Sarcopenia, the age-related decline of muscle, is a significant and growing public health
burden. C. elegans, a model organism for investigating the mechanisms of ageing, also …

Resistance exercise training (RET) can counteract negative features of muscle ageing but
older age associates with reduced adaptive capacity to RET. Altered muscle protein …

Background Skeletal muscle atrophy manifests across numerous diseases; however, the
extent of similarities/differences in causal mechanisms between atrophying conditions in …

Although muscle atrophy is a serious problem during spaceflight, little is known about the
sequence of molecular events leading to atrophy in response to microgravity. We carried out …

While spaceflight is becoming more common than before, the hazards spaceflight and space
microgravity pose to the human body remain relatively unexplored. Astronauts experience …

Acute onset of organ failure in heatstroke is triggered by rhabdomyolysis of skeletal muscle.
Here, we showed that elevated temperature increases free cytosolic Ca2+ [Ca2+] f from …