Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that
assembles at the core promoter is required for the opening of the duplex DNA and …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work
indicated that the nuclear periphery provides the architectural basis for integration site …

HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier
of the nuclear pore complex and deliver the genome directly into the nucleus,. Remarkably …

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the
alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich …

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However …

Bidirectional transport of macromolecules across the nuclear envelope is a hallmark of
eukaryotic cells, in which the genetic material is compartmentalized inside the nucleus. The …

HIV-1 integration favors nuclear speckle (NS)-proximal chromatin and viral infection induces
the formation of capsid-dependent CPSF6 condensates that colocalize with nuclear …

The Karyopherin-β family of proteins mediates nuclear transport of macromolecules. Nuclear
versus cytoplasmic localization of proteins is often suggested by the presence of NLSs …