Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line
FE Bennani, L Doudach, Y Cherrah, Y Ramli… - Bioorganic …, 2020 - Elsevier
Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …
Pyrazoline hybrids as promising anticancer agents: An up-to-date overview
D Matiadis, M Sagnou - International Journal of Molecular Sciences, 2020 - mdpi.com
Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …
attracted significant attention from organic and medicinal chemists due to their potent …
Photocatalytic cyclization of nitrogen-centered radicals with carbon nitride through promoting substrate/catalyst interaction
The use of metal-free carbon nitride and light to drive catalytic transformations constitutes a
sustainable strategy for organic synthesis. At the moment, enhancing the intrinsic activity of …
sustainable strategy for organic synthesis. At the moment, enhancing the intrinsic activity of …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
Antimicrobial, antioxidant, and anticancer activities of some novel isoxazole ring containing chalcone and dihydropyrazole derivatives
Our previous work identified isoxazole-based chalcones and their dihydropyrazole
derivatives as two important five-membered heterocycles having antitubercular activity …
derivatives as two important five-membered heterocycles having antitubercular activity …
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
The features of the chemistry of 4-thiazolidinone and pyrazole/pyrazolines as
pharmacologically attractive scaffolds were described in a number of reviews in which the …
pharmacologically attractive scaffolds were described in a number of reviews in which the …
Copper Makes the Difference: Visible Light-Mediated Atom Transfer Radical Addition Reactions of Iodoform with Olefins
S Engl, O Reiser - ACS Catalysis, 2020 - ACS Publications
Herein, we report a visible light-mediated copper-catalyzed protocol enabling the highly
economic, vicinal difunctionalization of olefins utilizing the readily available bulk chemical …
economic, vicinal difunctionalization of olefins utilizing the readily available bulk chemical …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …