Astrocyte-neuron metabolic cooperation shapes brain activity

G Bonvento, JP Bolaños - Cell metabolism, 2021 - cell.com
The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

[HTML][HTML] Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2018 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Identification of region-specific astrocyte subtypes at single cell resolution

MY Batiuk, A Martirosyan, J Wahis, F de Vin… - Nature …, 2020 - nature.com
Astrocytes, a major cell type found throughout the central nervous system, have general
roles in the modulation of synapse formation and synaptic transmission, blood–brain barrier …

[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits

J Nagai, X Yu, T Papouin, E Cheong, MR Freeman… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

Glutamate hypothesis in schizophrenia

Y Uno, JT Coyle - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …

Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells

Y Liu, X Shen, Y Zhang, X Zheng, C Cepeda, Y Wang… - Glia, 2023 - Wiley Online Library
The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …

Astrocytes and behavior

P Kofuji, A Araque - Annual review of neuroscience, 2021 - annualreviews.org
Animal behavior was classically considered to be determined exclusively by neuronal
activity, whereas surrounding glial cells such as astrocytes played only supportive roles …

Brain energy metabolism: astrocytes in neurodegenerative diseases

Z Chen, Z Yuan, S Yang, Y Zhu, M Xue… - CNS neuroscience & …, 2023 - Wiley Online Library
Astrocytes are the most abundant cells in the brain. They have many important functions in
the central nervous system (CNS), including the maintenance of glutamate and ion …

The tripartite glutamatergic synapse

U Lalo, W Koh, CJ Lee, Y Pankratov - Neuropharmacology, 2021 - Elsevier
Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …

Astroglial CB1 receptors determine synaptic D-serine availability to enable recognition memory

LM Robin, JFO da Cruz, VC Langlais… - Neuron, 2018 - cell.com
Bidirectional communication between neurons and astrocytes shapes synaptic plasticity and
behavior. D-serine is a necessary co-agonist of synaptic N-methyl-D-aspartate receptors …