The molecular biology of pestiviruses
N Tautz, BA Tews, G Meyers - Advances in virus research, 2015 - Elsevier
Pestiviruses are among the economically most important pathogens of livestock. The biology
of these viruses is characterized by unique and interesting features that are both crucial for …
of these viruses is characterized by unique and interesting features that are both crucial for …
RNA-based viral vectors
MA Mogler, KI Kamrud - Expert Review of Vaccines, 2015 - Taylor & Francis
The advent of reverse genetic approaches to manipulate the genomes of both positive (+)
and negative (−) sense RNA viruses allowed researchers to harness these genomes for …
and negative (−) sense RNA viruses allowed researchers to harness these genomes for …
Construction and efficacy of a new live chimeric C-strain vaccine with DIVA characteristics against classical swine fever
W Yi, H Wang, H Qin, Q Wang, R Guo, G Wen, Z Pan - Vaccine, 2023 - Elsevier
To develop the new classical swine fever (CSF) vaccine candidate with differentiating
infected vaccinated animals (DIVA) characteristics, a chimeric CSF virus (CSFV) was …
infected vaccinated animals (DIVA) characteristics, a chimeric CSF virus (CSFV) was …
Synthesizing evidence and identifying knowledge gaps in the role of swine in Japanese encephalitis virus transmission: a rapid systematic review of the literature
V Horton, CJ Hanthorn, AL Dixon… - … in Sustainable Food …, 2024 - frontiersin.org
The United States is considered a susceptible region with great potential for the introduction
of the Japanese encephalitis virus (JEV) given the presence of competent mosquito vector …
of the Japanese encephalitis virus (JEV) given the presence of competent mosquito vector …
Proline to threonine mutation at position 162 of NS5B of classical swine fever virus vaccine C strain promoted genome replication and infectious virus production by …
H Pang, L Li, H Liu, Z Pan - Viruses, 2021 - mdpi.com
The 3′ untranslated region (3′ UTR) and NS5B of classical swine fever virus (CSFV) play
vital roles in viral genome replication. In this study, two chimeric viruses, vC/SM3′ UTR and …
vital roles in viral genome replication. In this study, two chimeric viruses, vC/SM3′ UTR and …
A Genetically Engineered Bivalent Vaccine Coexpressing a Molecular Adjuvant against Classical Swine Fever and Porcine Epidemic Diarrhea
H Wang, W Yi, H Qin, Q Wang, R Guo… - International Journal of …, 2023 - mdpi.com
Classical swine fever (CSF) and porcine epidemic diarrhea (PED) are highly contagious
viral diseases that pose a significant threat to piglets and cause substantial economic losses …
viral diseases that pose a significant threat to piglets and cause substantial economic losses …
A positively charged surface patch on the pestivirus NS3 protease module plays an important role in modulating NS3 helicase activity and virus production
F Zheng, W Yi, W Liu, H Zhu, P Gong, Z Pan - Archives of Virology, 2021 - Springer
Abstract Pestivirus nonstructural protein 3 (NS3) is a multifunctional protein with protease
and helicase activities that are essential for virus replication. In this study, we used a …
and helicase activities that are essential for virus replication. In this study, we used a …
Identification of two amino acids within E2 important for the pathogenicity of chimeric classical swine fever virus
R Wu, L Li, Y Zhao, J Tu, Z Pan - Virus Research, 2016 - Elsevier
Our previous study demonstrated that a chimeric classical swine fever virus (CSFV)
vSM/CE2 containing the E2 gene of the vaccine C-strain on the genetic background of the …
vSM/CE2 containing the E2 gene of the vaccine C-strain on the genetic background of the …
Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3
F Zheng, G Lu, L Li, P Gong, Z Pan - Journal of Virology, 2017 - Am Soc Microbiol
The nonstructural protein NS3 from the Flaviviridae family is a multifunctional protein that
contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral …
contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral …
Development of a novel single-step reverse genetics system for the generation of classical swine fever virus
L Li, H Pang, R Wu, Y Zhang, Y Tan, Z Pan - Archives of virology, 2016 - Springer
We describe an alternative reverse genetics system for generating classical swine fever
virus (CSFV) based on swine RNA polymerase I promoter (pSPI)-mediated vRNA …
virus (CSFV) based on swine RNA polymerase I promoter (pSPI)-mediated vRNA …