Microneedles invade skin tissue in a minimally invasive manner, with a small traumatic
surface and slight pain. There is growing interest in the potential application of microneedle …

Baclofen (BAC) is the first-line recommendation to treat spasticity in people with multiple
sclerosis whose treatment goals include improving mobility or easing pain. The short half-life …

As a non-invasive dosage form, transdermal targeted drug delivery system avoids first-pass
effect, improves and maintains blood drug concentration, reduces gastrointestinal …

NAL's hydrophilicity and the inherent lipophilic properties of the stratum corneum hinders its
capacity for immediate delivery through skin in opioid rescue cases. In this study, we had …

The transdermal delivery of naloxone for opioid overdose emergency purposes is a
challenge due to its poor rate of diffusion through the layers of skin. This results in delayed …

Background: Microneedle patch (MNP) technology is now applied for many purposes,
including transdermal drug delivery and percutaneous collagen induction in the cosmetic …

Atopic dermatitis is a chronic inflammatory disorder with rising prevalence. The safety
concerns over usually used steroids are driving the need for developing an effective atopic …

Polymeric microneedle (MN)-based patches are an efficient, non-invasive, and painless
means of drug delivery through the skin to systemic circulation. The design of these MN …

In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical
skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used …

Transdermal Drug Delivery (TDD) is a non-painful way of systemically delivering
medications by applying a drug formulation to intact, healthy skin. The drug particles' …