Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular
components in tissues. In addition to functioning as a structural scaffold for cellular …

Simple Summary Dose and efficacy of radiation therapy are limited by the toxicity to normal
tissue adjacent to the treated tumor region. Recently, ultra-high dose rate radiotherapy …

Metabolic programming is emerging as a critical mechanism to alter immune cell activation,
differentiation and function. Targeting metabolism does not completely suppress or activate …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …

The precursor cells for metabolically beneficial beige adipocytes can alternatively become
fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic …

Background: Marfan syndrome (MFS) is an autosomal dominant disorder of the connective
tissue caused by mutations in the FBN1 (fibrillin-1) gene encoding a large glycoprotein in …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …