New molecular therapies for the treatment of hearing loss

Y Ma, AK Wise, RK Shepherd… - Pharmacology & …, 2019 - Elsevier
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …

Hair cell regeneration

ASB Edge, ZY Chen - Current opinion in neurobiology, 2008 - Elsevier
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory
cells required for hearing and balance. Recent studies in both lower vertebrates and …

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors

W Chen, N Jongkamonwiwat, L Abbas, SJ Eshtan… - Nature, 2012 - nature.com
Deafness is a condition with a high prevalence worldwide, produced primarily by the loss of
the sensory hair cells and their associated spiral ganglion neurons (SGNs). Of all the forms …

Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in …

JH Reyes, KS O'Shea, NL Wys, JM Velkey… - Journal of …, 2008 - Soc Neuroscience
Differentiation of the pluripotent neuroepithelium into neurons and glia is accomplished by
the interaction of growth factors and cell-type restricted transcription factors. One approach …

[HTML][HTML] Progress in modeling and targeting inner ear disorders with pluripotent stem cells

PC Tang, E Hashino, RF Nelson - Stem Cell Reports, 2020 - cell.com
Sensorineural hearing loss and vestibular dysfunction are caused by damage to neurons
and mechanosensitive hair cells, which do not regenerate to any clinically relevant extent in …

[HTML][HTML] Sensational placodes: neurogenesis in the otic and olfactory systems

EC Maier, A Saxena, B Alsina, ME Bronner… - Developmental …, 2014 - Elsevier
For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly
radial arrangement of the sensory neurons in the nose, numerous signaling molecules and …

Monitoring in vitro neural stem cell differentiation based on surface-enhanced Raman spectroscopy using a gold nanostar array

WA El-Said, SU Kim, JW Choi - Journal of Materials Chemistry C, 2015 - pubs.rsc.org
The development of neurochips for non-invasive monitoring of neural stem cell stimulation is
highly desirable and can enable the efficient optimization of tissue development protocols …

Differentiation of adult mouse olfactory precursor cells into hair cells in vitro

KL Doyle, A Kazda, Y Hort, SM McKay… - Stem cells, 2007 - academic.oup.com
Many forms of deafness result from degeneration of the sensory cells for hearing, the hair
cells in the cochlea. Stem cells offer a potential cell-based therapy for the treatment of …

Bone marrow mesenchymal stem cells differentiate into urothelial cells and the implications for reconstructing urinary bladder mucosa

J Ning, C Li, H Li, J Chang - Cytotechnology, 2011 - Springer
To determine the ability of cultured bone marrow-derived mesenchymal stem cells (BMSCs)
to differentiate into functional urothelium. BMSCs were isolated from the long bones of …

Nanobiosensing platforms for real-time and non-invasive monitoring of stem cell pluripotency and differentiation

IR Suhito, N Angeline, SS Choo, HY Woo, T Paik, T Lee… - Sensors, 2018 - mdpi.com
Breakthroughs in the biomedical and regenerative therapy fields have led to the influential
ability of stem cells to differentiate into specific types of cells that enable the replacement of …