Does siponimod exert direct effects in the central nervous system?

M Kipp - Cells, 2020 - mdpi.com
The modulation of the sphingosine 1-phosphate receptor is an approved treatment for
relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes …

Regional contribution of vascular dysfunction in white matter dementia: clinical and neuropathological insights

J Pansieri, G Hadley, A Lockhart, M Pisa… - Frontiers in …, 2023 - frontiersin.org
The maintenance of adequate blood supply and vascular integrity is fundamental to ensure
cerebral function. A wide range of studies report vascular dysfunction in white matter …

Radiomics models based on cortical damages for identification of multiple sclerosis with cognitive impairment

Z Yan, S Yuan, Q Zhu, X Wang, Z Shi, Y Zhang… - Multiple Sclerosis and …, 2024 - Elsevier
Background Cognitive impairment (CI) is a common symptom in multiple sclerosis (MS)
patients. Cortical damages can be closely associated with cognitive network dysfunction and …

Characterization of thalamic lesions and their correlates in multiple sclerosis by ultra-high-field MRI

A Mehndiratta, CA Treaba, V Barletta… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background: Thalamic pathology is a marker for neurodegeneration and multiple sclerosis
(MS) disease progression. Objective: To characterize (1) the morphology of thalamic …

The role of 7 T MRI to assess atrophy of the subcortical deep gray matter in relapsing–remitting multiple sclerosis

AM Callen, J Zurawski, R Chu, Y Tie, S Tauhid… - Journal of …, 2024 - Springer
Background Deep gray matter (DGM) atrophy and lesions are found in multiple sclerosis
(MS). Objective To optimize automated segmentation for 7 T DGM volumetrics and assess …

Radiomics Nomograms Based on Multi-sequence MRI for Identifying Cognitive Impairment and Predicting Cognitive Progression in Relapsing-Remitting Multiple …

X Wang, S Liu, Z Yan, F Yin, J Feng, H Liu, Y Liu… - Academic Radiology, 2024 - Elsevier
Rationale and Objectives To build radiomics nomograms based on multi-sequence MRI to
facilitate the identification of cognitive impairment (CI) and prediction of cognitive …

[HTML][HTML] In vivo tensor-valued diffusion MRI of focal demyelination in white and deep grey matter of rodents

Y He, S Aznar, HR Siebner, TB Dyrby - NeuroImage: Clinical, 2021 - Elsevier
Background Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease leading
to damage of white matter (WM) and grey matter (GM). Magnetic resonance imaging (MRI) is …

[HTML][HTML] Volumetric and Asymmetric Index Analysis of Subcortical Structures in Multiple Sclerosis Patients: A Retrospective Study Using volBrain Software

A Tekin, B Rende, H Efendi, SD Bunul, Ö Çakır… - Cureus, 2024 - ncbi.nlm.nih.gov
Methods In our retrospective investigation, we admitted 100 Turkish individuals, comprising
50 patients diagnosed with relapsing-remitting MS (RRMS)(24 (48%) males and 26 (52%) …

Magnetic Resonance Imaging of Multiple Sclerosis Pathology: Computer Aided Detection and Monitoring

ST Govindarajan - 2020 - search.proquest.com
Multiple sclerosis (MS) is a neurological disease where a person's own immune system
attacks their brain and spinal cord. The brain is the most complex organ in the human body …