Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers

KS Kim, M Iwamoto, K Kitagawa, H Park… - PLOS Computational …, 2025 - journals.plos.org
Quantification of intrahepatic covalently closed circular DNA (cccDNA) is a key for evaluating
an elimination of hepatitis B virus (HBV) in infected patients. However, quantifying cccDNA …

Multiscale modeling of HBV infection integrating intra-and intercellular viral propagation to analyze extracellular viral markers

K Kitagawa, KS Kim, M Iwamoto… - PLOS Computational …, 2024 - journals.plos.org
Chronic infection with hepatitis B virus (HBV) is caused by the persistence of closed circular
DNA (cccDNA) in the nucleus of infected hepatocytes. Despite available therapeutic anti …

[HTML][HTML] Positivity preserving numerical method for epidemic model of hepatitis B disease dynamic with delay factor

MA ur Rehman, M Kazim, N Ahmed, A Raza… - Alexandria Engineering …, 2023 - Elsevier
This work attempts to study the numerical solution of nonlinear delayed Immunized
Susceptible Latent Infected and Recovered (MSLIR) epidemic model of HBV disease …

A Semi‐mechanistic Model to Characterize the Long‐Term Dynamics of Hepatitis B Virus Markers During Treatment With Lamivudine and Pegylated Interferon

S El Messaoudi, A Lemenuel‐Diot… - Clinical …, 2023 - Wiley Online Library
Antiviral treatments against hepatitis B virus (HBV) suppress viral replication but do not
eradicate the virus, and need therefore to be taken lifelong to avoid relapse. Mathematical …

[HTML][HTML] Dysregulation of hepatitis B virus nucleocapsid assembly in vitro by RNA-binding small ligands

N Patel, F Abulwerdi, F Fatehi, IW Manfield… - Journal of molecular …, 2022 - Elsevier
RNA sequences/motifs dispersed across the genome of Hepatitis B Virus regulate formation
of nucleocapsid-like particles (NCPs) by core protein (Cp) in vitro, in an epsilon/polymerase …

[HTML][HTML] Multiscale modeling of HBV infection integrating intra-and intercellular viral propagation for analyzing extracellular viral markers

K Kitagawa, KS Kim, M Iwamoto, S Hayashi, H Park… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Chronic infection of hepatitis B virus (HBV) is caused by the persistence of closed circular
DNA (cccDNA) in the nucleus of infected hepatocytes. Despite available therapeutic anti …

Numerical study of chronic hepatitis B infection using Marchuk–Petrov model

M Khristichenko, Y Nechepurenko… - … of Bioinformatics and …, 2023 - World Scientific
In this work, we briefly describe our technology developed for computing periodic solutions
of time-delay systems and discuss the results of computing periodic solutions for the …

Global Stability of a Viral Infection Model with Defectively Infected Cells and Latent Age

J Li, Y Chen, P Zhang, D Zhang - Chinese Annals of Mathematics, Series B, 2024 - Springer
The authors propose and analyze a viral infection model with defectively infected cells and
age of the latently infected cells. The existence of steady states is determined by the basic …

Dependence of optimal disturbances on periodic solution phases for time-delay systems

MY Khristichenko, YM Nechepurenko… - Russian Journal of …, 2023 - degruyter.com
The paper is focused on the dependence of optimal disturbances of stable periodic solutions
of time-delay systems on phases of such solutions. The results of numerical experiments …

The role of interleukin-10 in immune response to hepatitis B virus and liver cancer co-existence dynamics

P Chataa, SM Naandam, F Djankpa - medRxiv, 2024 - medrxiv.org
Experimental evidence confirms that interleukin-10 plays a critical role in clearing acute
hepatitis B virus infection. This paper aims to develops a mathematical model to explore the …