▪ Abstract Completion of the cell cycle requires the temporal and spatial coordination of
chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding …

Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components
of pathways that control important cellular processes, such as morphological changes …

Appropriate cell number and organ size in a multicellular organism are determined by
coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can …

Exit from mitosis in budding yeast requires a group of essential proteins—including the
GTPase Tem1 and the protein phosphatase Cdc14—that downregulate cyclin-dependent …

Introns have typically been discovered in an ad hoc fashion: introns are found as a gene is
characterized for other reasons. As complete eukaryotic genome sequences become …

MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes. This family of
potentially dual-specific protein kinases is among several that regulate a number of steps of …

A conserved signalling cascade—termed the mitotic-exit network in budding yeast and the
septation-initiation network in fission yeast—controls key events during exit from mitosis and …

Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinase–cyclin
complexes, primarily by ubiquitin-dependent cyclin proteolysis. Cyclin destruction is …

The events of late mitosis, from sister-chromatid separation to cytokinesis, are governed by
the anaphase-promoting complex (APC), a multisubunit assembly that triggers the ubiquitin …

Cytokinesis is the final event of the cell division cycle, and its completion results in
irreversible partition of a mother cell into two daughter cells. Cytokinesis was one of the first …