Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Bile acids participate in the intestinal emulsion, digestion, and absorption of lipids and fat-
soluble vitamins. When present in high concentrations, as in cholestatic liver diseases, bile …

It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown
aetiology for which there are no approved therapeutic options. Patients with PSC display …

Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics,
cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic …

Objective Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and
experimental models. Goal: define the function of complex resident microbes and their …

Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …

Biliary atresia is a rare cholestatic liver disease that presents in infants and rapidly advances
to death in the absence of intervention. As a result of blockage or destruction of the biliary …

Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In
addition, currently available in vitro methods do not allow for the estimation of hepatotoxic …

Cell survival rate determines engraftment efficiency in adipose-derived mesenchymal stem
cell (ADSC)-based regenerative medicine. In vivo monitoring of ADSC viability to achieve …