Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Human aldo-keto reductases (AKRs) catalyze the NADPH-dependent reduction of carbonyl
groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to …

Background Cisplatin is the first-line chemotherapy used against most upper aerodigestive
tract carcinomas. In head and neck cancer, sensitivity to cisplatin remains the key issue in …

Morin, a bioactive flavonoid extracted from the bark of Moraceae plants and many medicinal
herbs, has anti-inflammatory and antioxidative effects. In this research, we explored the …

Oxaliplatin is a first-line therapy for colorectal cancer, but cancer cell resistance to the drug
compromises its efficacy. To explore mechanisms of drug resistance, we treated colorectal …

Fenamates as classical nonsteroidal anti‐inflammatory agents are widely used for relieving
pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and …

This study was conducted to investigate the effects of oridonin (ORI) on growth performance
and antioxidant capacity in broiler chickens that were repeatedly challenged with …

In treating bladder cancer, determining the molecular mechanisms of tumor invasion,
metastasis, and drug resistance are urgent to improving long-term patient survival. One of …

Simple Summary The aldehyde dehydrogenases enzymes (ALDHs) are promising drug
targets in cancer therapy. ALDHs are members of an enzymatic superfamily composed by …