Antigen receptor T cells (CAR-T) effectively control tumor growth in a colorectal liver metastasis model

LF Chai, JC Hardaway, KR Heatherton… - Journal of Surgical …, 2022 - Elsevier
Background Effective treatment of solid tumors requires multi-modality approaches. In many
patients with stage IV liver disease, current treatments are not curative. Chimeric antigen …

Regional delivery of anti-PD-1 agent for colorectal liver metastases improves therapeutic index and anti-tumor activity

LF Chai, JC Hardaway, KR Heatherton, KP O'Connell… - Vaccines, 2021 - mdpi.com
Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors
(CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can …