Emerging frontiers in drug delivery

MW Tibbitt, JE Dahlman, R Langer - Journal of the American …, 2016 - ACS Publications
Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …

Supramolecular polymeric hydrogels

EA Appel, J del Barrio, XJ Loh… - Chemical Society …, 2012 - pubs.rsc.org
The supramolecular crosslinking of polymer chains in water by specific, directional and
dynamic non-covalent interactions has led to the development of novel supramolecular …

Self-assembled hydrogels utilizing polymer–nanoparticle interactions

EA Appel, MW Tibbitt, MJ Webber, BA Mattix… - Nature …, 2015 - nature.com
Mouldable hydrogels that flow on applied stress and rapidly self-heal are increasingly
utilized as they afford minimally invasive delivery and conformal application. Here we report …

In situ-forming injectable hydrogels for regenerative medicine

JA Yang, J Yeom, BW Hwang, AS Hoffman… - Progress in polymer …, 2014 - Elsevier
Regenerative medicine involves interdisciplinary biomimetic approaches for cell therapy
and tissue regeneration, employing the triad of cells, signals, and/or scaffolds. Remarkably …

Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review

S Van Vlierberghe, P Dubruel, E Schacht - Biomacromolecules, 2011 - ACS Publications
Hydrogels are physically or chemically cross-linked polymer networks that are able to
absorb large amounts of water. They can be classified into different categories depending …

Injectable matrices and scaffolds for drug delivery in tissue engineering

JD Kretlow, L Klouda, AG Mikos - Advanced drug delivery reviews, 2007 - Elsevier
Injectable matrices and depots have been the subject of much research in the field of drug
delivery. The classical tissue engineering paradigm includes a matrix or scaffold to facilitate …

Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system.

PY Dankers, TM Hermans, TW Baughman… - … (Deerfield Beach, Fla …, 2012 - europepmc.org
A modular one-component supramolecular transient network in water, based on poly
(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to …

Injectable hydrogels for bone and cartilage tissue engineering: a review

N Olov, S Bagheri-Khoulenjani, H Mirzadeh - Progress in Biomaterials, 2022 - Springer
Tissue engineering, using a combination of living cells, bioactive molecules, and three-
dimensional porous scaffolds, is a promising alternative to traditional treatments such as the …

Injectable biomaterials for regenerating complex craniofacial tissues

JD Kretlow, S Young, L Klouda, M Wong… - Advanced …, 2009 - Wiley Online Library
Engineering complex tissues requires a precisely formulated combination of cells,
spatiotemporally released bioactive factors, and a specialized scaffold support system …

In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular Engineering

KM Park, JA Yang, H Jung, J Yeom, JS Park, KH Park… - ACS …, 2012 - ACS Publications
A facile in situ supramolecular assembly and modular modification of biocompatible
hydrogels were demonstrated using cucurbit [6] uril-conjugated hyaluronic acid (CB [6]-HA) …