FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

K Wang, Y Zhang, G Wang, H Hao… - Medicinal Research …, 2024 - Wiley Online Library
Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver
disease, is the most common liver disease worldwide and has no approved …

Precision medicine in fatty liver disease/non-alcoholic fatty liver disease

L Valenzuela-Vallejo, D Sanoudou… - Journal of Personalized …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, and is
related to fatal and non-fatal liver, metabolic, and cardiovascular complications. Its non …

[HTML][HTML] Review on chronic metabolic diseases surrounding bile acids and gut microbiota: What we have explored so far

Z Zhu, Y Xu, Y Xia, X Jia, Y Chen, Y Liu, L Zhang… - Life Sciences, 2024 - Elsevier
Bile acid, the final product of cholesterol breakdown, functions as a complex regulator and
signaling factor in human metabolism. Chronic metabolic diseases pose significant medical …

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency

C Zhang, Y Zhang, B Liu, Y Chen, Y Xie… - Journal of Proteome …, 2024 - ACS Publications
Protein S deficiency (PSD) is an autosomal dominant disorder characterized by congenital
thrombophilia. Studies on PSD are limited yet, resulting in a lack of clarity about molecular …

Huang Zhen mycoplasm polysaccharides mitigate nonalcoholic fatty liver disease induced by a high-fat diet in mice: Evidence from hepatic metabolomics

Y Wu, F Xu, Z Song, H Jiang, S Li, G Huo… - International Journal of …, 2024 - Elsevier
HZMP-1 is a new polysaccharide isolated from Huang Zhen mycoplasm that contains seven
monosaccharides, and it has an average molecular weight of 16.817 kDa. Its structural …

Influence of Gut Microbiota and its Metabolites on Progression of Metabolic Associated Fatty Liver Disease

YY Wang, HL Lin, KL Wang, GX Que, T Cao… - Chinese Medical …, 2023 - Elsevier
Metabolic associated fatty liver disease (MAFLD) has become a prevalent chronic liver
disease worldwide because of lifestyle and dietary changes. Gut microbiota and its …

[HTML][HTML] 非酒精性脂肪性肝病多组学研究现状

段明秀, 陈新利, 常伟宇, 杨媛, 杨仕琦, 吴晖 - 临床肝胆病杂志, 2024 - lcgdbzz.com
非酒精性脂肪性肝病(NAFLD) 在全球范围内患病率高达30%, 严重影响人类健康并构成公共
卫生负担. 由于该病难以诊断和监控, 因此, 识别潜在的药物靶点和生物标志物具有重要价值 …

A Narrative Overview of Retinoid X Receptor Inhibitors in Chronic Disease Management

CR Wei, M Osama, S Tahir - Current Drug Research Reviews, 2024 - benthamdirect.com
The Retinoid X Receptor (RXR) is a member of the nuclear receptor superfamily and
regulates gene transcription as well as diverse cellular processes like metabolism …

Advances in the multi-omics research on nonalcoholic fatty liver disease

M Duan, X Chen, W Chang, Y Yang… - Journal of Clinical …, 2024 - pesquisa.bvsalud.org
The prevalence rate of nonalcoholic fatty liver disease (NAFLD) reaches up to 30% around
the world, and the disease has a serious impact on human health and constitutes a public …