Saponins in cancer treatment: Current progress and future prospects

OO Elekofehinti, O Iwaloye, F Olawale, EO Ariyo - Pathophysiology, 2021 - mdpi.com
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

FRS Passos, HG Araújo-Filho, BS Monteiro… - Phytomedicine, 2022 - Elsevier
Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

Ophiopogon japonicus—A phytochemical, ethnomedicinal and pharmacological review

MH Chen, XJ Chen, M Wang, LG Lin… - Journal of …, 2016 - Elsevier
Abstract Ethnopharmacological relevance Ophiopogonis Radix (Maidong in Chinese), the
root of Ophiopogon japonicus, is widely used in local medicines of China, Japan and some …

Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia

D Nalini, J Selvaraj, GS Kumar - Journal of Cancer Research and Clinical …, 2020 - Springer
Purpose Growing solid tumors mostly outstrip blood supply and become hypoxic (low
oxygen supply). To survive under this pathological milieu, tumors overexpress a potent …

Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms

Q Liu, JJ Lu, HJ Hong, Q Yang, Y Wang, XJ Chen - Phytomedicine, 2023 - Elsevier
Abstract Background Ophiopogon japonicus (Thunb.) Ker Gawl., a well-known Chinese
herb, has been used in traditional Chinese medicine for thousands of years. Extensive in …

Xiaoaiping induces developmental toxicity in zebrafish embryos through activation of ER stress, apoptosis and the Wnt pathway

J Li, Y Zhang, K Liu, Q He, C Sun, J Han… - Frontiers in …, 2018 - frontiersin.org
The aim of the study was to determine the developmental toxicity of the traditional Chinese
medicine Xiaoaiping (XAP) and to investigate its underlying mechanism of action. Zebrafish …

The saponin D39 blocks dissociation of non‐muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis

K Zhai, J Zheng, Y Tang, F Li, Y Lv… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Non‐muscular myosin heavy chain IIA (NMMHC IIA) plays a key
role in tissue factor expression and venous thrombosis. Natural products might inhibit …

Marsdenia tenacissima extract induces G0/G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling …

F Wei, S Li, Z Jing-Qian, C Zhang, Q Song… - Chinese journal of …, 2015 - Elsevier
Marsdenia tenacissima extract (MTE, trade name: Xiao-Ai-Ping injection) is an extract of a
single Chinese plant medicine. It has been used for the treatment of cancer in China for …

DT-13 inhibited the proliferation of colorectal cancer via glycolytic metabolism and AMPK/mTOR signaling pathway

X Wei, T Mao, S Li, J He, X Hou, H Li, M Zhan, X Yang… - Phytomedicine, 2019 - Elsevier
Background Emerging hallmark of cancer is reprogrammed cellular metabolism, increased
glycolytic metabolism is physiological characteristic of human malignant neoplasms …

Anticancer Activity of Saponins from Allium chinense against the B16 Melanoma and 4T1 Breast Carcinoma Cell

Z Yu, T Zhang, F Zhou, X Xiao, X Ding… - Evidence‐Based …, 2015 - Wiley Online Library
The cytotoxic substance of A. chinense saponins (ACSs) was isolated using ethanol
extraction and purified with the D101 macroporous adsorption resin approach. We …