The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …

Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …

Mast cells are unique tissue‐resident immune cells that secrete a diverse array of
biologically active compounds that can stimulate, modulate, or suppress the immune …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

OBJECTIVES: Diarrhea-predominant irritable bowel syndrome (IBS-D) patients show altered
epithelial permeability and mucosal micro-inflammation in both proximal and distal regions …

Mast cells (MC) are a bone marrow-derived, long-lived, heterogeneous cellular population
that function both as positive and negative regulators of immune responses. They are …

Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new
perspective in light of the recent advances in research. Although classical NEPC is rarely …