Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …

Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

Organoids—Preclinical Models of Disease An organoid is a three-dimensional construct
composed of multiple cell types that originates from stem cells through self-organization and …

Abstract Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important
potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute …

Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-
thirds of patients with metastases progress within two years. Here we report the identification …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …

The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

As of December 2021, SARS-CoV-2 had caused over 250 million infections and 5 million
deaths worldwide. Furthermore, despite the development of highly effective vaccines, novel …

Conventional two-dimensional cell monolayers do not provide the geometrical, biochemical
and mechanical cues found in real tissues. Cells in real tissues interact through chemical …