Challenges of HIV diagnosis and management in the context of pre‐exposure prophylaxis (PrEP), post‐exposure prophylaxis (PEP), test and start and acute HIV …

T Elliott, EJ Sanders, M Doherty… - African Journal of …, 2019 - journals.lww.com
Introduction: Knowledge of HIV status relies on accurate HIV testing, and is the first step
towards access to HIV treatment and prevention programmes. Globally, HIV-status …

p24 revisited: a landscape review of antigen detection for early HIV diagnosis

ER Gray, R Bain, O Varsaneux, RW Peeling… - Aids, 2018 - journals.lww.com
Despite major advances in HIV testing, early detection of infection at the point of care (PoC)
remains a key challenge. Although rapid antibody PoC and laboratory-based nucleic acid …

Initiation of antiretroviral therapy during acute HIV-1 infection leads to a high rate of nonreactive HIV serology

MS de Souza… - Reviews of Infectious …, 2016 - academic.oup.com
Background. Third-and fourth-generation immunoassays (IAs) are widely used in the
diagnosis of human immunodeficiency virus (HIV) infection. Antiretroviral therapy (ART) …

A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation

A Violari, MF Cotton, L Kuhn, DB Schramm… - Nature …, 2019 - nature.com
Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART)
soon after infection and then discontinued, may inform HIV cure interventions. Here we …

Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children

L Kuhn, M Paximadis, B Da Costa Dias, S Loubser… - PloS one, 2018 - journals.plos.org
Background The latent viral reservoir is the major obstacle to achieving HIV remission and
necessitates life-long antiretroviral therapy (ART) for HIV-infected individuals. Studies in …

HIV and solid organ transplantation: where are we now

J Botha, J Fabian, H Etheredge, F Conradie… - Current HIV/AIDS …, 2019 - Springer
Abstract Purpose of Review We review the international evolution of HIV and solid organ
transplantation over 30 years. We emphasise recent developments in solid organ …

Lessons in diagnostic virology: expected and unexpected sources of error

G van Zyl, J Maritz, H Newman… - Reviews in medical …, 2019 - Wiley Online Library
Viral diagnostics have shown continued innovation, with serological and molecular
diagnostic assays pushing the limits of sensitivity. Technology has provided new automated …

The CARMA Study: early infant antiretroviral therapy—timing impacts on total HIV-1 DNA quantitation 12 years later

C Foster, S Domínguez-Rodríguez… - Journal of the …, 2021 - academic.oup.com
Background Strategies aimed at antiretroviral therapy (ART)–free remission will target
individuals with a limited viral reservoir. We investigated factors associated with low …

Living donor liver transplant from an HIV-positive mother to her HIV-negative child: opening up new therapeutic options

J Botha, F Conradie, H Etheredge, J Fabian, M Duncan… - Aids, 2018 - journals.lww.com
Objective: Transplant a liver from an HIV-positive mother to her HIV-negative child to save
the child's life. Design: A unique case of living donor liver transplantation from an HIV …

Decreased seroreactivity in individuals initiating antiretroviral therapy during acute HIV infection

MM Manak, LL Jagodzinski, A Shutt… - Journal of clinical …, 2019 - Am Soc Microbiol
Antiretroviral therapy (ART) during acute HIV infection (AHI) interrupts viral dynamics and
may delay the emergence of serological markers targeted by current HIV screening and …