Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Potassium (K+) ion channel activity is an important determinant of vascular tone by
regulating cell membrane potential (MP). Activation of K+ channels leads to membrane …

Chronic angiotensin II (Ang II) infusion, in rats fed high salt, engages the sympathetic
nervous system to increase venomotor tone. The splanchnic sympathetic nervous system is …

Cardiovascular diseases (CVDs) are a set of heart and blood vessel disorders that include
coronary heart disease (CHD), rheumatic heart disease, and other conditions. Traditional …

Emerging evidence from genome‐wide association studies (GWAS) support the association
of polymorphisms in the alpha 1C subunit of the L‐type voltage‐gated calcium channel gene …

Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across
the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs) …

Small arteries in the body control vascular resistance, and therefore, blood pressure and
blood flow. Endothelial and smooth muscle cells in the arterial walls respond to various …

Ion channels that influence membrane potential and intracellular calcium concentration
control vascular smooth muscle excitability. Voltage-gated calcium channels (VGCC) …

Ischemic stroke causes a heavy health burden worldwide, with over 10 million new cases
every year. Despite the high prevalence and mortality rate of ischemic stroke, the underlying …

Background and purpose: Reduction of intracellular calcium ([Ca2+] i) in smooth muscle
cells (SMCs) is an important mechanism by which nitric oxide (NO) dilates blood vessels …