TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

J Peng, M Fan, C An, F Ni, W Huang… - Basic & clinical …, 2022 - Wiley Online Library
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …

Antioxidative and anti-inflammatory properties of cannabidiol

S Atalay, I Jarocka-Karpowicz, E Skrzydlewska - Antioxidants, 2019 - mdpi.com
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …

Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Cannabinoid ligands targeting TRP channels

C Muller, P Morales, PH Reggio - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Transient receptor potential (TRP) channels are a group of membrane proteins involved in
the transduction of a plethora of chemical and physical stimuli. These channels modulate ion …

New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Molecular targets of the phytocannabinoids: a complex picture

P Morales, DP Hurst, PH Reggio - Phytocannabinoids: Unraveling the …, 2017 - Springer
For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa
L., have been used for their medicinal, as well as, their psychotropic effects. These effects …

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

T Huang, T Xu, Y Wang, Y Zhou, D Yu, Z Wang, L He… - Autophagy, 2021 - Taylor & Francis
Glioma is the most common primary malignant brain tumor with poor survival and limited
therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been …

Immune responses regulated by cannabidiol

JM Nichols, BLF Kaplan - Cannabis and cannabinoid research, 2020 - liebertpub.com
Introduction: Cannabidiol (CBD) as Epidiolex®(GW Pharmaceuticals) was recently
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …