Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

The development of endurance exercise paradigms in Drosophila has facilitated study of
genetic factors that control individual response to exercise. Recent work in Drosophila has …

Background Exercise exerts remarkably powerful effects on metabolism and health, with anti-
disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits …

Regular physical exercise is the most efficient and accessible intervention known to promote
healthy aging in humans. The molecular and cellular mechanisms that mediate system-wide …

Endurance exercise has broadly protective effects across organisms, increasing metabolic
fitness and reducing incidence of several age-related diseases. Drosophila has emerged as …

Exercise is one of the most effective treatments for the diseases of aging. In recent years, a
growing number of researchers have used Drosophila melanogaster to study the broad …

High-Fat-Diet (HFD)-induced obesity is a major contributor to heart and mobility premature
aging and mortality in both Drosophila and humans. The dSir2 genes are closely related to …

Because of the growing rates of obesity in much of the world, exercise as a treatment option
for obesity and as part of a healthy lifestyle is of great interest to the general public, health …

Exercise is recommended to promote health and prevent a range of diseases. However,
how exercise precipitates these benefits is unclear, nor do we understand why exercise …

Recent studies indicate that physical activity can slow down progression of
neurodegeneration in humans. To date, automated ways to induce activity have been …