On the cellular and network bases of epileptic seizures

DA McCormick, D Contreras - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …

Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats

AML Coenen, E Van Luijtelaar - Behavior genetics, 2003 - Springer
Based on the reviewed literature and the data presented in this paper, conclusions can be
drawn with respect to the validity of the WAG/Rij strain of rats as a model for absence …

Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats

HKM Meeren, JPM Pijn… - Journal of …, 2002 - Soc Neuroscience
Absence seizures are the most pure form of generalized epilepsy. They are characterized in
the electroencephalogram by widespread bilaterally synchronous spike-wave discharges …

Childhood absence epilepsy: genes, channels, neurons and networks

V Crunelli, N Leresche - Nature Reviews Neuroscience, 2002 - nature.com
Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a
multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and …

Thalamic mechanisms of EEG alpha rhythms and their pathological implications

SW Hughes, V Crunelli - The Neuroscientist, 2005 - journals.sagepub.com
During relaxed wakefulness, the human brain exhibits pronounced rhythmic electrical
activity in the α frequency band (8-13 Hz). This activity consists of 3 main components: the …

Pathophysiological mechanisms of genetic absence epilepsy in the rat

L Danober, C Deransart, A Depaulis, M Vergnes… - Progress in …, 1998 - Elsevier
Generalized non-convulsive absence seizures are characterized by the occurrence of
synchronous and bilateral spike and wave discharges (SWDs) on the electroencephalogram …

Cellular and network mechanisms of spike‐wave seizures

H Blumenfeld - Epilepsia, 2005 - Wiley Online Library
Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform
defect present in all patients and involvement of the whole brain homogenously. Here, we …

Serotonin and epilepsy

G Bagdy, V Kecskemeti, P Riba… - Journal of …, 2007 - Wiley Online Library
In recent years, there has been increasing evidence that serotonergic neurotransmission
modulates a wide variety of experimentally induced seizures. Generally, agents that elevate …

Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor‐independent mechanism

TDM Hill, MG Cascio, B Romano… - British journal of …, 2013 - Wiley Online Library
Background and Purpose Epilepsy is the most prevalent neurological disease and is
characterized by recurrent seizures. Here, we investigate (i) the anticonvulsant profiles of …

fMRI activation during spike and wave discharges in idiopathic generalized epilepsy

Y Aghakhani, AP Bagshaw, CG Benar, C Hawco… - Brain, 2004 - academic.oup.com
The objectives of this study were to evaluate the haemodynamic response of the cerebral
cortex and thalamus during generalized spike and wave or polyspike and wave (GSW) …