The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

For more than three decades, the ability of a fluorine atom involved in a C–F bond to act as a
hydrogen-bond acceptor has been a controversial issue. Throughout the years, more and …

Fluorine atoms confer desirable biophysical, chemical, and biological properties to
peptides/proteins by participating in various intermolecular interactions with their …

The mechanism and origin of the unexpected chemoselectivity in fluorocyclization of o-styryl
benzamide with a cyclic hypervalent fluoroiodane reagent were explored with DFT …

It is known that the fluoro group has only a small effect on the rates of electrophilic aromatic
substitutions. Imagine instead a carbon–fluorine (C− F) bond positioned tightly over the π …

The bench-stable cyclic hypervalent fluoroiodane reagent (1) is receiving increasing
attention in fluorine chemistry because of its completely new reactivity. Fluorination …

Theoretical decomposition of “through space” spin–spin coupling constants (SSCCs) in
organofluorine compounds signal that intramolecular hydrogen bonds (H-bonds) are not the …

Aryl-triazole oligomers based on isobutyl 4-fluorobenzoate and isobutyl 4-chlorobenzoate
were designed and synthesized. Crystal structure and 1H–1H NOESY experiments …

Reported herein is the synthesis of a molecule containing an unusually strong hydrogen
bond between an OH donor and a covalent F acceptor, a heretofore somewhat ill‐defined if …

Solid solutions (SS) of benzoic acid (BA) and 4-fluorobenzoic acid (4FBA) are monitored
with respect to increasing fluorine content. All 10 SS studied take a crystal structure that is …