Fibronectin (FN) is a multidomain protein with the ability to bind simultaneously to cell
surface receptors, collagen, proteoglycans, and other FN molecules. Many of these domains …

It is now accepted that the growth of solid tumours is dependent on their capacity to acquire
a blood supply, and much effort has been directed towards the development of agents …

Glioblastoma is a poorly immunogenic cancer, and the successes with recent
immunotherapies in extracranial malignancies have, so far, not been translated to this …

A secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in
hamster cells has been found to be similar to a fragment of the platelet and matrix protein …

Glioblastoma is the most aggressive primary brain tumor with an unmet need for more
effective therapies. Here, we investigated combination therapies based on L19TNF, an …

Tumor-associated macrophages (TAMs) are key orchestrators of the tumor
microenvironment directly affecting neoplastic cell growth, neoangiogenesis, and …

When messenger RNA precursors (pre-mRNAs) containing alternative 5'splice sites are
spliced in vitro, the relative concentrations of the heterogeneous ribonucieoprotein(hnRNP) …

We report the construction and the use of a phage display human antibody library (> 3× 10 8
clones) based on principles of protein design. A large repertoire of functional antibodies with …

The adhesive extracellular matrix glycoprotein fibronectin (FN) is thought to play an
important role in the cell migration associated with wound healing. Immunolocalization …

Airway hyperresponsiveness leading to subepithelial fibrosis is mediated by inflammatory
cells activated by T helper (Th) 2-derived cytokines such as IL-4 and IL-5. By analyzing the …