Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that
they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP …

Rho GTPases are well known to regulate actin dynamics. They activate two types of actin
nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce …

Determinants of membrane targeting of Rho proteins were investigated in live cells with
green fluorescent fusion proteins expressed with or without Rho-guanine nucleotide …

The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases.
To date, 22 human genes encoding at least 25 proteins have been described. The best …

Since their discovery in the late eighties, the role of Rho GTPases in the regulation of cell
migration has been extensively studied and has mainly focused on the hallmark family …

The human genomic sequencing effort has revealed the presence of a large number of Rho
GTPases encoded by the human genome. Here we report the characterization of a new …

Abstract The small GTPase Rab5 regulates membrane docking and fusion in the early
endocytic pathway. Here we reveal a new role for Rab5 in the regulation of endosome …

Numerous virus families utilize endocytosis to infect host cells, mediating virus
internalization as well as trafficking to the site of replication. Recent research has …