Tissue regeneration after damage is generally thought to involve the mobilization of adult
stem cells that divide and differentiate into progressively specialized progeny. However …

Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been
key challenges to effective treatment for patients. It has been suggested that a subpopulation …

Liver injuries often occur in a zonated manner. However, detailed regenerative responses to
such zonal injuries at cellular and molecular levels remain largely elusive. By using a fate …

Ionizing radiation induces cell death in the gastrointestinal (GI) epithelium by activating p53.
However, p53 also prevents animal lethality caused by radiation-induced acute GI …

ABSTRACT PTPRK is a receptor tyrosine phosphatase that is linked to the regulation of
growth factor signalling and tumour suppression. It is stabilized at the plasma membrane by …

Cell state dynamics underlying successful tissue regeneration are undercharacterized. In
the intestine, damage prompts epithelial reprogramming into revival stem cells (revSCs) that …

The human intestinal epithelium is a tissue with rapid turnover. Its complex regenerative
process and differentiation trajectories have been challenging to study due to its …

Stem cells play pivotal roles in maintaining intestinal homeostasis, orchestrating
regeneration, and in key steps of colorectal cancer (CRC) initiation and progression …

Thrombospondin-1 (TSP1) is a matricellular protein associated with the regulation of cell
migration through direct binding interactions with integrin proteins and by associating with …

Cancer stem cells (CSCs) are a long‐lived and self‐renewing cancer cell population that
drives tumor propagation and maintains cancer heterogeneity. They are also implicated in …