Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges

S Dutta, S Hornung, HB Taha, G Bitan - Acta neuropathologica, 2023 - Springer
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …

The emerging role of exosomes in Alzheimer's disease

T Zhang, S Ma, J Lv, X Wang, HK Afewerky, H Li… - Ageing research …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), manifested by memory loss and a decline in cognitive
functions, is the most prevalent neurodegenerative disease accounting for 60–80% of …

Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases

X Xia, Y Wang, JC Zheng - Translational Neurodegeneration, 2022 - Springer
Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by
all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as …

Engineered EVs designed to target diseases of the CNS

L Nieland, S Mahjoum, E Grandell, K Breyne… - Journal of Controlled …, 2023 - Elsevier
Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …

Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction

C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …

The role of necroptosis in cerebral ischemic stroke

Q Wang, F Yang, K Duo, Y Liu, J Yu, Q Wu… - Molecular Neurobiology, 2024 - Springer
Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes
and is the leading cause of disability worldwide. Due to disrupted blood supply to the brain …

Emergence of extracellular vesicles as “liquid biopsy” for neurological disorders: boom or bust

A Kumar, MA Nader, G Deep - Pharmacological Reviews, 2024 - ASPET
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …

[HTML][HTML] Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway

W Ding, Q Gu, M Liu, J Zou, J Sun, J Zhu - International …, 2023 - Elsevier
Background Our previous studies have shown that berberine can improve the nerve function
deficits in ischemic stroke by inhibiting inflammation. The cellular communication between …

[HTML][HTML] Extracellular vesicles for the diagnosis and treatment of Parkinson's disease

R Upadhya, AK Shetty - Aging and disease, 2021 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) shed by neurons and glia in the central nervous system carry a
cargo of specific bioactive molecules, facilitating intercellular communication. However, in …

[HTML][HTML] Extracellular vesicles derived from astrocyte-treated with haFGF14-154 attenuate Alzheimer phenotype in AD mice

D Peng, Y Wang, Y Xiao, M Peng, W Mai, B Hu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: aFGF content in serum and cerebrospinal fluid is increased in Alzheimer's
disease (AD) patients and attenuates the activation of astrocytes. Extracellular vesicles …