GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma

P Silva-Rodríguez, D Fernández-Díaz, M Bande… - Cancers, 2022 - mdpi.com
Simple Summary The development of uveal melanoma is a multifactorial and multi-step
process, in which specific and recurrent mutations arise early. Among the recurrently …

Imaging of uveal melanoma—Current standard and methods in development

M Solnik, N Paduszyńska, AM Czarnecka… - Cancers, 2022 - mdpi.com
Simple Summary Uveal melanoma is the most prevalent intraocular tumor in adults, derived
from melanocytes; the liver is the most common site of its metastases. Due to troublesome …

Uveal melanoma metastasis

E Rossi, M Croce, F Reggiani, G Schinzari, M Ambrosio… - Cancers, 2021 - mdpi.com
Simple Summary Survival after diagnosis of metastatic uveal melanoma has not significantly
improved over decades, most patients die within a year from diagnosis. Uveal melanoma is …

Uveal melanoma diagnosis and current treatment options

DC Branisteanu, CM Bogdanici… - Experimental and …, 2021 - spandidos-publications.com
Uveal melanoma is a rare condition accounting for only 5% of all primary melanoma cases.
Still, it is the most frequently diagnosed primary intraocular malignant tumor in adults. Almost …

Prognostic biomarkers in uveal melanoma: The status quo, recent advances and future directions

NJ Lamas, A Martel, S Nahon-Estève, S Goffinet… - Cancers, 2021 - mdpi.com
Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Genetic and Epigenetic Features of Uveal Melanoma—An Overview and Clinical Implications

D Pašalić, T Nikuševa-Martić, A Sekovanić… - International journal of …, 2023 - mdpi.com
Uveal melanoma (UM) is rare, but it is the most common primary intraocular malignancy
among adults. This review represents the molecular, genetic, and immunobiological …

Genetic landscape and emerging therapies in uveal melanoma

RS Seedor, M Orloff, T Sato - Cancers, 2021 - mdpi.com
Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for …

Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part II: Treatment indications and complications

PV Foti, M Travali, R Farina, S Palmucci, C Spatola… - Insights into …, 2021 - Springer
Therapy of uveal melanoma aims to preserve the eye and its function and to avoid
metastatic dissemination. The treatment choice is difficult and must keep into account …

Meta-analysis of isolated hepatic perfusion and percutaneous hepatic perfusion as a treatment for uveal melanoma liver metastases

MS Bethlehem, D Katsarelias, R Olofsson Bagge - Cancers, 2021 - mdpi.com
Simple Summary Isolated hepatic perfusion is one of the available treatment options for
patients with liver metastases from uveal melanoma. This is an open surgical procedure …

Uveal melanoma cell line proliferation is inhibited by ricolinostat, a histone deacetylase inhibitor

H Sundaramurthi, S García-Mulero, V Tonelotto… - Cancers, 2022 - mdpi.com
Simple Summary Uveal melanoma (UM) is the most common adult eye cancer. UM
originates in the iris, ciliary body or choroid (collectively known as the uvea), in the middle …