The glucocorticoid receptor (GR), like many signaling proteins, depends on the Hsp90
molecular chaperone for in vivo function. Although Hsp90 is required for ligand binding in …

Most high-grade serous ovarian cancer (HGSOC) patients develop resistance to platinum-
based chemotherapy and recur, but 15% remain disease free over a decade. To discover …

The mission of the DNASU Plasmid Repository is to accelerate research by providing high-
quality, annotated plasmid samples and online plasmid resources to the research …

Proteins destined for the cell surface are first assessed in the endoplasmic reticulum (ER) for
proper folding before release into the secretory pathway. This ensures that defective …

Cancer cells can undergo a metabolic reprogramming from oxidative phosphorylation to
glycolysis that allows them to adapt to nutrient-poor microenvironments, thereby imposing a …

Integrating research into the classroom environment is an influential pedagogical tool to
support student learning, increase retention of STEM students, and help students identify as …

Protein glycosylation events that happen early in the secretory pathway are often
dysregulated during tumorigenesis. These events can be probed, in principle, by …

Recycling of membrane proteins enables the reuse of receptors, ion channels and
transporters. A key component of the recycling machinery is the endosomal sorting complex …

The non-canonical NF-κB signalling cascade is essential for lymphoid organogenesis, B cell
maturation, osteoclast differentiation, and inflammation in mammals,; dysfunction of this …

Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis
and for mediating necroptotic parthanatos; these functions are seemingly regulated by …