Behavioural phenotyping assays for mouse models of autism

JL Silverman, M Yang, C Lord… - Nature Reviews …, 2010 - nature.com
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …

Translational animal models of autism and neurodevelopmental disorders

JN Crawley - Dialogues in clinical neuroscience, 2012 - Taylor & Francis
Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral
criteria: unusual reciprocal social interactions, deficits in communication, and stereotyped …

Autism‐like behavioral phenotypes in BTBR T+ tf/J mice

HG McFarlane, GK Kusek, M Yang… - Genes, Brain and …, 2008 - Wiley Online Library
Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse
models with face validity to the core symptoms offer an experimental approach to test …

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains

SS Moy, JJ Nadler, NB Young, A Perez… - Behavioural brain …, 2007 - Elsevier
Three defining clinical symptoms of autism are aberrant reciprocal social interactions,
deficits in social communication, and repetitive behaviors, including motor stereotypies and …

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

S Jamain, K Radyushkin… - Proceedings of the …, 2008 - National Acad Sciences
Autism spectrum conditions (ASCs) are heritable conditions characterized by impaired
reciprocal social interactions, deficits in language acquisition, and repetitive and restricted …

Behavioral phenotypes of genetic mouse models of autism

TM Kazdoba, PT Leach… - Genes, Brain and …, 2016 - Wiley Online Library
More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism

JL Silverman, DG Smith, SJS Rizzo… - Science translational …, 2012 - science.org
Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to
be medically untreatable, on the assumption that brain dysfunctions were immutably …

[HTML][HTML] Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

A Sato, S Kasai, T Kobayashi, Y Takamatsu… - Nature …, 2012 - nature.com
Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder.
Genetic disorders frequently accompany autism spectrum disorder, such as tuberous …

[HTML][HTML] Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice

JB Panksepp, KA Jochman, JU Kim, JJ Koy, ED Wilson… - PloS one, 2007 - journals.plos.org
Social approach is crucial for establishing relationships among individuals. In rodents, social
approach has been studied primarily within the context of behavioral phenomena related to …

[HTML][HTML] Modelling autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) using mice and zebrafish

G Dougnon, H Matsui - International journal of molecular sciences, 2022 - mdpi.com
Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two
debilitating neurodevelopmental disorders. The former is associated with social impairments …