Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …

Glaucoma is a progressive, age-related optic neuropathy and a leading cause of irreversible
blindness in the world. Animal models of glaucoma are essential to our continued efforts of …

Purpose.: Retrograde neurotrophic factor transport blockade has been implicated in the
pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some …

Increased intraocular pressure (IOP) damages the retinal ganglion cell axons as they pass
through the optic nerve head (ONH). The massive connective tissue structure of the human …

Ocular hypertension (OHT) is the main risk factor of glaucoma, a neuropathy leading to
blindness. Here we have investigated the effects of laser photocoagulation (LP)-induced …

Purpose.: The development of a method for the sustained elevation of intraocular pressure
in experimental glaucoma based on the anterior chamber injection of paramagnetic …

Understanding the molecular mechanism of glaucoma and development of neuroprotectants
is significantly hindered by the lack of a reliable animal model that accurately recapitulates …

Understanding mechanisms of glaucomatous optic nerve damage is essential for
developing effective therapies to augment conventional pressure-lowering treatments. This …

The neurotrophin (NT) hypothesis proposes that the obstruction of retrograde transport at the
optic nerve head results in the deprivation of neurotrophic support to retinal ganglion cells …

Purpose To investigate the effects of laser photocoagulation (LP)-induced ocular
hypertension (OHT) on the survival and retrograde axonal transport of retinal ganglion cells …